DHFR-IN-23

DHFR-IN-23 (compound 5) is a dual DNA binders/DHFR inhibitor, with an IC50 of 0.08 μM for hDHFR. DHFR-IN-23 (compound 5) is also an apoptosis inducer. DHFR-IN-23 (compound 5) can be used for the research of ER+ breast cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Dihydrofolate reductase (DHFR)

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

O=C(O)C(/C=C/C1=CC=C(Cl)C=C1)=N\NC2=NC(C3=CC=CC=C3)=CS2

Molecular Formula

C19H14ClN3O2S

Molecular Weight

383.85

References & Citations

[1]Marwa H, et al. Rational design, synthesis, and molecular modelling insights of dual DNA binders/DHFR inhibitors bearing arylidene-hydrazinyl-1,3-thiazole scaffold with apoptotic and anti-migratory potential in breast MCF-7 cancer cells. Journal of Enzyme Inhibition and Medicinal Chemistry Volume 40, 2025 - Issue 1.