Anti-NSCLC agent-1
Anti-NSCLC agent-1 (compound 8dc) is an inhibitor of tyrosine kinase inhibitors (TKIs) with IC50 values of 0.05 and 0.09 μM in A549 and NCI-H441 cells. anti-NSCLC agent-1 shows anti-NSCLC activities in colony formation, migration, and invasion[1].
Product Specifications
UNSPSC
12352005
Target
EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(CC1=CC=CS1)N(CC2)CC3=C2C4=CC=CC(C(NC5CCC(O)C5)=O)=C4N3
Molecular Formula
C23H25N3O3S
Molecular Weight
423.53
References & Citations
[1]Jie Zhang, et al; Discovery of novel small molecules targeting TGF-β signaling for the treatment of non-small cell lung cancer. Eur J Med Chem. 2025 May 5:289:117442.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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