FLT3-ITD-IN-3
FLT3-ITD-IN-3 (13v), an orally active FLT3-ITD (FLT3 internal tandem duplication) inhibitor, disrupts FLT3 signal transduction and induced G0/G1 cell cycle arrest and apoptosis. FLT3-ITD-IN-3 (13v) is used in the research of acute myeloid leukemia (AML) [1].
Product Specifications
CAS Number
[3018150-80-3]
UNSPSC
12352005
Target
Apoptosis; FLT3
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(C(C(C)=C1)=NN(C2=CC(Cl)=CC=C2F)C1=O)NC3=CC=C(OC4=CC(NC(N5CC(O)C5)=O)=NC=C4)C(F)=C3
Molecular Formula
C27H21ClF2N6O5
Molecular Weight
582.94
References & Citations
[1]Shengfei Wu, et al. Design, synthesis, and biological evaluation of 4- (2-fluorophenoxy) pyridine derivatives as novel FLT3-ITD inhibitors. Eur J Med Chem. 2025 May 5:289:117492.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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