NLRP3-IN-73
NLRP3-IN-73 (W16) is an orally active inhibitor of the assembly of NLRP3 inflammasome via targeting NLRP3, with an IC50 value of 0.18 μM for the NLRP3/IL-1β pathway[1].
Product Specifications
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
CC[C@H](NC(C1=C(C)C(C2=CC=CC(F)=C2)=NC3=C1C=CC=C3[N+]([O-])=O)=O)C4=CC=CC=C4
Molecular Formula
C26H22FN3O3
Molecular Weight
443.47
References & Citations
[1]Ruiwen Wu, et al. Discovery, synthesis, and biological mechanism evaluation of novel quinoline derivatives as potent NLRP3 inhibitors. Eur J Med Chem. 2025 May 5:289:117466.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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