SK-124
SK-124 is an orally active, selective SIK2/SIK3 inhibitor. SK-124 inhibits SIK2 and SIK3. SK-124 increases P1NP and CTX. SK-124 increases bone formation and bone mass[1].
Product Specifications
CAS Number
2760404-50-8
UNSPSC
12352005
Target
Salt-inducible Kinase (SIK)
Related Pathways
Immunology/Inflammation
Field of Research
Endocrinology
Smiles
COC1=CC(C2=CN=C3C=C(C4=CN(C)N=C4)C=CN32)=CC(OC)=C1C5=NN=C(CC)O5
Molecular Formula
C23H22N6O3
Molecular Weight
430.46
References & Citations
[1]Sato T, et al. Structure-based design of selective, orally available salt-inducible kinase inhibitors that stimulate bone formation in mice. Proc Natl Acad Sci U S A. 2022 Dec 13;119 (50) :e2214396119.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIK2; SIK3
Frequently Asked Questions
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