SK-124

SK-124 is an orally active, selective SIK2/SIK3 inhibitor. SK-124 inhibits SIK2 and SIK3. SK-124 increases P1NP and CTX. SK-124 increases bone formation and bone mass[1].

Product Specifications

CAS Number

[2760404-50-8]

UNSPSC

12352005

Target

Salt-inducible Kinase (SIK)

Related Pathways

Immunology/Inflammation

Field of Research

Endocrinology

Smiles

COC1=CC(C2=CN=C3C=C(C4=CN(C)N=C4)C=CN32)=CC(OC)=C1C5=NN=C(CC)O5

Molecular Formula

C23H22N6O3

Molecular Weight

430.46

References & Citations

[1]Sato T, et al. Structure-based design of selective, orally available salt-inducible kinase inhibitors that stimulate bone formation in mice. Proc Natl Acad Sci U S A. 2022 Dec 13;119 (50) :e2214396119.