Antibacterial agent 271

Antibacterial agent 271 is an antibacterial agent with significant inhibition against Escherichia coli (MIC: 2.2 μM) . Antibacterial agent 271 reduces metabolic activity by disrupting the integrity of bacterial membranes. Antibacterial agent 271 binds to DNA grooves to inhibit replication and induces accumulation of reactive oxygen species (ROS), ultimately leading to bacterial death. Antibacterial agent 271 shows significant potential in combating bacterial infections[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial; DNA/RNA Synthesis; Reactive Oxygen Species (ROS)

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

NC1=CC=C(S(=O)(NC2=CC=C(C(CN3C(C)=NC=C3[N+]([O-])=O)=CC(O4)=O)C4=C2)=O)C=C1

Molecular Formula

C20H17N5O6S

Molecular Weight

455.44

References & Citations

[1]Wang YX, et al. Benzo-α-pyrone-derived multitargeting actions to enhance the antibacterial performance of sulfanilamides against Escherichia coli. Bioorg Chem. 2025 May;158:108339.