EGFR-IN-154
EGFR-IN-154 (compound 4c) is an EGFR inhibitor with EC50 values of 0.16 μM, 21.73 μM and 41.56 μM against EGFR Del19, EGFR WT and EGFR L858R, respectively. EGFR-IN-154 shows anticancer activity on various cance cell lines. EGFR-IN-154 induces mitochondrial apoptosis, and decreases pERK1/2 and pAkt levels, but increases pJNK and pp38 levels[1].
Product Specifications
UNSPSC
12352005
Target
Akt; EGFR; JNK; p38 MAPK; PERK
Related Pathways
Cell Cycle/DNA Damage; JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
N=C(NC1CC1)C(C=C2)=CC=C2NC3=NC=NC4=C3C=C(OC)C(OC)=C4
Molecular Formula
C20H21N5O2
Molecular Weight
363.41
References & Citations
[1]Acar Halıcı C, et al. Design, synthesis, and biological evaluation of novel amidoxime or amidine analogues of some 4-anilino-6,7-dimethoxyquinazolines with a potent EGFR inhibitory effect. Bioorg Chem. 2025 May;158:108345.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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