Keap1-Nrf2-IN-27
Keap1-Nrf2-IN-27 (compound 1C) is a inhibitor of Keap1-Nrf2 protein-protein interaction (PPI) with KD2 value of 0.119 μM. Keap1-Nrf2-IN-27 suppresses the expression of pro-inflammatory cytokine TNF-α and IL-6 in the LPS-induced RAW264.7 cell model[1].
Product Specifications
UNSPSC
12352005
Target
Keap1-Nrf2
Related Pathways
NF-κB
Field of Research
Inflammation/Immunology
Smiles
O=C(O)/C=C\C(NC1=CC=C(S(=O)(N(CC(N)=O)C2=C3C=CC=CC3=C(N(CC(N)=O)S(=O)(C4=CC=C(OC)C=C4)=O)C=C2)=O)C=C1)=O
Molecular Formula
C31H29N5O10S2
Molecular Weight
695.72
References & Citations
[1]Xiuting Qin, et al. Structure-based molecular hybridization design and synthesis of Keap1-Nrf2 inhibitors for anti-inflammatory treatment. Bioorg Chem. 2025 May:158:108350.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
124344-APC 100 µL
CARD8 (Caspase Recruitment Domain-containing Protein 8, Apoptotic Protein NDPP1, CARD-inhibitor of NF-kappa-B-activating Ligand, CARDINAL, DACAR, DAKAR, DKFZp779L0366, FLJ18119, FLJ18121, KIAA0955, MGC57162, NDPP1, NDPP, Tumor Up-regulated CARD-containing Antagonist of CASP9, TUCAN) (APC)
Ask
View Details 
