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TLK1-IN-1

TLK1-IN-1 (Compound 5n) is a TLK1 inhibitor with an IC50 of 7.2 μM against TLK1B and a GI50 of 2.7 μM in LNCaP cells. TLK1-IN-1 induces DNA damage and apoptosis in cancer cells, making it a potential candidate for prostate cancer research[1].

Product Specifications

UNSPSC

12352005

Target

Ser/Thr Kinase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

O=C(NC1=CC=C(Cl)C=C1)CN(N=C2)C(C3=C2C4=CC(Br)=CC=C4N3CCN5CCOCC5)=O

Molecular Formula

C24H23BrClN5O3

Molecular Weight

544.83

References & Citations

[1]Johnson D, et al. Characterization of new non-ATP dependent inhibitors of TLK1 as potential molecules for treating prostate cancer. Bioorg Chem. 2025 May;158:108317.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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