HDAC6-IN-53

HDAC6-IN-53 (Compound W28) is an inhibitor targeting histone deacetylase 6 (HDAC6) with an IC50 of 19.65 nM. HDAC6-IN-53 exerts the activity of inhibiting the phenotype of idiopathic pulmonary fibrosis (IPF) by suppressing the collagen expression induced by TGF-β1, and it has demonstrated a good therapeutic effect in a mouse model of pulmonary fibrosis induced by bleomycin (HY-108345) . HDAC6-IN-53 can be used in the research of idiopathic pulmonary fibrosis and other related pulmonary fibrosis diseases.

Product Specifications

CAS Number

[3081880-03-4]

UNSPSC

12352005

Target

HDAC

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Smiles

O=C(C1=CC=C(Br)C=C1)NCCC2=CN(CC3=CC=C(C(NO)=O)C=C3)C4=CC=C(OC)C=C42

Molecular Formula

C26H24BrN3O4

Molecular Weight

522.39

References & Citations

[1]Quan J, et al. Discovery of novel selective HDAC6 inhibitors via a scaffold hopping approach for the treatment of idiopathic pulmonary fibrosis (IPF) in vitro and in vivo. Bioorg Chem. 2025 Mar 11;159:108360.