Anticonvulsant agent 10

Anticonvulsant agent 10 (Compound 6d) is an inhibitor targeting the Keap1-Nrf2 interaction, with a potent ED50 of 0.04 mmol/kg. By inhibiting Keap1-Nrf2 binding and activating the Nrf2/ARE pathway, Anticonvulsant agent 10 exerts anticonvulsant and neuroprotective effects, making it suitable for research in antiepileptic and neuroprotective studies[1].

Product Specifications

UNSPSC

12352005

Target

Keap1-Nrf2

Related Pathways

NF-κB

Field of Research

Neurological Disease

Smiles

O=C(NC1=CC=NC=C1)C2(CCCCC2)NC3=CC=C(C=C3)OC

Molecular Formula

C19H23N3O2

Molecular Weight

325.40

References & Citations

[1]Abd-Allah WH, et al. Design and synthesis of novel cyclohexanecarboxamides with anticonvulsant effect by activating Nrf2-ARE pathway. Bioorg Chem. 2025 Mar 10;159:108357.