5-LOX-IN-8
5-LOX-IN-8 is a 5-LOX inhibitor with anti-inflammatory activity. 5-LOX-IN-8 suppresses IL-6, IL-1β, TNF-α and IFN-γ in macrophages and reduces IL-8 secretion in SW480 cells. 5-LOX-IN-8 reduces disease activity in a DSS colitis model. 5-LOX-IN-8 can be used for research of inflammatory bowel disease (IBD) [1].
Product Specifications
UNSPSC
12352005
Target
IFNAR; Interleukin Related; Lipoxygenase; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
COC1=C(OC)C(OC)=CC(CC2(CC3=CC(OC)=C(OC)C(OC)=C3)CC4=C(C=CC=C4)C2)=C1
Molecular Formula
C29H34O6
Molecular Weight
478.58
References & Citations
[1]Zhang T, et al. Bioactive Indanes: Design, synthesis and bioactivity investigation of 2,2-substituted Indane derivatives, a new bioactive Indane scaffold. Bioorg Chem. 2025 Mar 9;159:108352.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-LOX; IL-1; IL-6; IL-8
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