OA-Br-1

OA-Br-1 is an orally active and selective inhibitor of PTP1B with an IC50 value of 7.08 μM. OA-Br-1 induces apoptosis. OA-Br-1 has broad spectrum anti-proliferative activity against cancer cells, and plays an anti-breast cancer role through the PTP1B/PI3K/AKT signaling pathway both in vitro and in vivo[1].

Product Specifications

Product Name Alternative

3-O- (6-Bromo-D-mannosyl) -28-acylamino-n-caproate methyl oleanolic acid

UNSPSC

12352005

Target

Apoptosis; Phosphatase

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

BrC[C@H]1O[C@H](O[C@@H]2C(C)(C)[C@@](CC[C@]3(C)[C@]4([H])CC=C5[C@@]3(C)CC[C@]6(C(NCCCCCC(OC)=O)=O)[C@@]5([H])CC(C)(C)CC6)([H])[C@]4(C)CC2)[C@@H](O)[C@@H](O)[C@@H]1O

Molecular Formula

C43H70BrNO8

Molecular Weight

808.92

References & Citations

[1]Song X, et al. Discovery of novel oleanolic acid glycoside derivatives targeting PTP1B/PI3K/AKT signaling pathway for the treatment of breast cancer. Bioorg Chem. 2025 Apr;157:108296.