OA-Br-1
OA-Br-1 is an orally active and selective inhibitor of PTP1B with an IC50 value of 7.08 μM. OA-Br-1 induces apoptosis. OA-Br-1 has broad spectrum anti-proliferative activity against cancer cells, and plays an anti-breast cancer role through the PTP1B/PI3K/AKT signaling pathway both in vitro and in vivo[1].
Product Specifications
Product Name Alternative
3-O- (6-Bromo-D-mannosyl) -28-acylamino-n-caproate methyl oleanolic acid
UNSPSC
12352005
Target
Apoptosis; Phosphatase
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
BrC[C@H]1O[C@H](O[C@@H]2C(C)(C)[C@@](CC[C@]3(C)[C@]4([H])CC=C5[C@@]3(C)CC[C@]6(C(NCCCCCC(OC)=O)=O)[C@@]5([H])CC(C)(C)CC6)([H])[C@]4(C)CC2)[C@@H](O)[C@@H](O)[C@@H]1O
Molecular Formula
C43H70BrNO8
Molecular Weight
808.92
References & Citations
[1]Song X, et al. Discovery of novel oleanolic acid glycoside derivatives targeting PTP1B/PI3K/AKT signaling pathway for the treatment of breast cancer. Bioorg Chem. 2025 Apr;157:108296.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC472853-500 1x 500 µL
CD54 / ICAM-1 (15.2), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470096-500 1x 500 µL
Histone H1 (AE-4), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC740257-500 1x 500 µL
Cytokeratin, HMW (AE-3), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC401930-100 1x 100 µL
PAX5 / BSAP (Early B-Cell Marker) (PCRP-PAX5-1B1), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC042078-100 1x 100 µL
TCL1 (T-Cell Marker) (TCL1/2078), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details