EGFR/BRAFV600E-IN-4
EGFR/BRAFV600E-IN-4 (Compound 10f) is a dual EGFR and BRAFV600E inhibitor with IC50 values of 61 nM and 43 nM, respectively. EGFR/BRAFV600E-IN-4 arrests cell cycle, induces apoptosis in both early and late stages and inhibits cancer cells growth in vitro, and has a broad anticancer activity[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; EGFR; Raf
Related Pathways
Apoptosis; JAK/STAT Signaling; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
C1(SCC2=CC=CC=C2)=NN=C(C3=CC=C4NC(C5=CC=CC=C5)=NC4=C3)O1
Molecular Formula
C22H16N4OS
Molecular Weight
384.45
References & Citations
[1]Fatma Fouad Hagar, et al. New antiproliferative 1,3,4-oxadiazole/benzimidazole derivatives: Design, synthesis, and biological evaluation as dual EGFR and BRAFV600E inhibitors. Bioorganic Chemistry. Volume 157, April 2025, 108297.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf; EGFR/ErbB1/HER1
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