BMS-185354
BMS-185354 is a selective RARγ activator with an EC50 value of 28 nM. BMS-185354 is promising for research of cancers[1].
Product Specifications
CAS Number
[110952-22-2]
UNSPSC
12352005
Target
RAR/RXR
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
O=C(C1=CC2=CC=C(/C(C3=CC=C4C(C(C)(CCC4(C)C)C)=C3)=N/O)C=C2C=C1)O
Molecular Formula
C26H27NO3
Molecular Weight
401.50
References & Citations
[1]Ostrowski J, et al. Serine 232 and methionine 272 define the ligand binding pocket in retinoic acid receptor subtypes. J Biol Chem. 1998 Feb 6;273 (6) :3490-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RXRγ
Curated Selection
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