AUR1545
AUR1545 is a selective degrader of KAT2A and KAT2B. AUR1545 can be used in the cancer research, including studies on AML (Acute myeloid leukemia), SCLC (Small-cell carcinoma), and NEPC (Neuroendocrine Prostate Cancer) [1].
Product Specifications
CAS Number
[3031593-79-7]
UNSPSC
12352005
Target
Histone Acetyltransferase
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.58
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C2=CC=C(N3CCN(CC3)CC4CCN(CC4)C(C5=CC=C([C@H]6C[C@H](CN(C6)C)NC7=C(C(N(N=C7)C)=O)Br)C=C5)=O)C=C2CN1C8C(NC(CC8)=O)=O
Molecular Formula
C41H50BrN9O5
Molecular Weight
828.80
References & Citations
[1]Kimberly S. Straley, et al. Abstract 5795: Potent and selective degradation of KAT2A and KAT2B induces profound cell state changes and inhibits growth of AML, SCLC and NEPC model systems. Cancer Res (2024) 84 (6_Supplement) : 5795.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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