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AKT1-IN-9

AKT1-IN-9 (4) is a selective mutant AKT1 (E17K) inhibitor, with EC50 values of 9 nM and 995 nM in LAPC4-CR and SkBr3 cells, respectively[1].

Product Specifications

UNSPSC

12352005

Target

Akt

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Purity

99.79

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CC1=CC=C(C([H])=O)C(O)=C1F)NCC(C=C2)=CC=C2N3C(C4=C(N)N=CC=C4)=NC5=C3N=C(C=C5)C6=CC=CC=C6

Molecular Formula

C33H25FN6O3

Molecular Weight

572.59

References & Citations

[1]Gregory B Craven, et al. Mutant-selective AKT inhibition through lysine targeting and neo-zinc chelation. Nature. 2025 Jan;637 (8044) :205-214.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Akt1

Available Sizes

Frequently Asked Questions

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