AKT1-IN-9
AKT1-IN-9 (4) is a selective mutant AKT1 (E17K) inhibitor, with EC50 values of 9 nM and 995 nM in LAPC4-CR and SkBr3 cells, respectively[1].
Product Specifications
UNSPSC
12352005
Target
Akt
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.79
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CC1=CC=C(C([H])=O)C(O)=C1F)NCC(C=C2)=CC=C2N3C(C4=C(N)N=CC=C4)=NC5=C3N=C(C=C5)C6=CC=CC=C6
Molecular Formula
C33H25FN6O3
Molecular Weight
572.59
References & Citations
[1]Gregory B Craven, et al. Mutant-selective AKT inhibition through lysine targeting and neo-zinc chelation. Nature. 2025 Jan;637 (8044) :205-214.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt1
Available Sizes
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