NK7-902 (diTFA)

NK7-902 diTFA is an orally active CRBN molecular glue degrader of NEK7. NK7-902 diTFA fully degrades NEK7 in human primary monocytes and whole blood but only partially inhibits NLRP3-dependent IL-1β production. NK7-902 diTFA leads to profound and long-lasting NEK7 degradation but only transiently blocks NLRP3 inflammasome activation in non-human primates by oral administration. NK7-902 diTFA shows activity in murine systems[1].

Product Specifications

UNSPSC

12352005

Target

Molecular Glues; NEKs

Related Pathways

Cell Cycle/DNA Damage; PROTAC

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Purity

98.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCN[C@@H]1CC[C@@H]2N(C3=CC=C(C(N(C4CCC(NC4=O)=O)C5=O)=O)C5=C3)[C@H]1CC2.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

Molecular Formula

C26H28F6N4O8

Molecular Weight

638.51

References & Citations

[1]Sylvain A, et, al. A cereblon (CRBN) molecular glue degrader of NIMA-related kinase 7 (NEK7) reveals a context-dependent role in NLRP3 inflammasome activation. bioRxiv. 2024.11.06.622079.