NK7-902 (diTFA)
NK7-902 diTFA is an orally active CRBN molecular glue degrader of NEK7. NK7-902 diTFA fully degrades NEK7 in human primary monocytes and whole blood but only partially inhibits NLRP3-dependent IL-1β production. NK7-902 diTFA leads to profound and long-lasting NEK7 degradation but only transiently blocks NLRP3 inflammasome activation in non-human primates by oral administration. NK7-902 diTFA shows activity in murine systems[1].
Product Specifications
UNSPSC
12352005
Target
Molecular Glues; NEKs
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Purity
98.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCN[C@@H]1CC[C@@H]2N(C3=CC=C(C(N(C4CCC(NC4=O)=O)C5=O)=O)C5=C3)[C@H]1CC2.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O
Molecular Formula
C26H28F6N4O8
Molecular Weight
638.51
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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