BRAFV600E/JNK-IN-1
BRAFV600E/JNK-IN-1 (Compound 14c) is an inhibitor of JNK1, JNK2, JNK3 and BRAFV600E, with IC50 values of 0.51 μM, 0.53 μM, 1.02 μM and 0.009 μM, respectively. BRAFV600E/JNK-IN-1 can inhibit the phosphorylation of MEK1/2 and ERK1/2. In addition, BRAFV600E/JNK-IN-1 can inhibit tumor cell proliferation, NO release and PGE2 production, and has anti-tumor and anti-inflammatory activities[1].
Product Specifications
UNSPSC
12352005
Target
JNK; MEK; NO Synthase; PERK
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway
Field of Research
Cancer; Inflammation/Immunology
Smiles
OC1=CC(C2=NN(CC)C=C2C3=CC=NC(NCCCNS(=O)(C4=CC=C(Cl)C=C4)=O)=N3)=CC=C1
Molecular Formula
C24H25ClN6O3S
Molecular Weight
513.01
References & Citations
[1]Abdel-Maksoud MS, et al. Design and synthesis of novel pyrimidine-pyrazole hybrids with dual anticancer and anti-inflammatory effects targeting BRAFV600E and JNK. Mol Divers. 2025 Feb 22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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