BRAFV600E/JNK-IN-1

BRAFV600E/JNK-IN-1 (Compound 14c) is an inhibitor of JNK1, JNK2, JNK3 and BRAFV600E, with IC50 values of 0.51 μM, 0.53 μM, 1.02 μM and 0.009 μM, respectively. BRAFV600E/JNK-IN-1 can inhibit the phosphorylation of MEK1/2 and ERK1/2. In addition, BRAFV600E/JNK-IN-1 can inhibit tumor cell proliferation, NO release and PGE2 production, and has anti-tumor and anti-inflammatory activities[1].

Product Specifications

UNSPSC

12352005

Target

JNK; MEK; NO Synthase; PERK

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway

Field of Research

Cancer; Inflammation/Immunology

Smiles

OC1=CC(C2=NN(CC)C=C2C3=CC=NC(NCCCNS(=O)(C4=CC=C(Cl)C=C4)=O)=N3)=CC=C1

Molecular Formula

C24H25ClN6O3S

Molecular Weight

513.01

References & Citations

[1]Abdel-Maksoud MS, et al. Design and synthesis of novel pyrimidine-pyrazole hybrids with dual anticancer and anti-inflammatory effects targeting BRAFV600E and JNK. Mol Divers. 2025 Feb 22.