BRAFV600E/JNK-IN-1
BRAFV600E/JNK-IN-1 (Compound 14c) is an inhibitor of JNK1, JNK2, JNK3 and BRAFV600E, with IC50 values of 0.51 μM, 0.53 μM, 1.02 μM and 0.009 μM, respectively. BRAFV600E/JNK-IN-1 can inhibit the phosphorylation of MEK1/2 and ERK1/2. In addition, BRAFV600E/JNK-IN-1 can inhibit tumor cell proliferation, NO release and PGE2 production, and has anti-tumor and anti-inflammatory activities[1].
Product Specifications
UNSPSC
12352005
Target
JNK; MEK; NO Synthase; PERK
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway
Field of Research
Cancer; Inflammation/Immunology
Smiles
OC1=CC(C2=NN(CC)C=C2C3=CC=NC(NCCCNS(=O)(C4=CC=C(Cl)C=C4)=O)=N3)=CC=C1
Molecular Formula
C24H25ClN6O3S
Molecular Weight
513.01
References & Citations
[1]Abdel-Maksoud MS, et al. Design and synthesis of novel pyrimidine-pyrazole hybrids with dual anticancer and anti-inflammatory effects targeting BRAFV600E and JNK. Mol Divers. 2025 Feb 22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC040977-100 1x 100 µL
TGF-beta (1D11.16.8), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC400031-100 1x 100 µL
Mucin 5AC (MUC5AC) (45M1), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 