YAP-IN-1
YAP-IN-1 (Compound (+) -1) is an autophagy (Autophagy) inhibitor targeting YAP1. YAP-IN-1 binds to the Hippo pathway transcription factor YAP1 with a Kd of 9.13 μM and induces its degradation via the chaperone-mediated autophagy (CMA) pathway. This process inhibits Rab7-mediated fusion of autophagosomes and lysosomes, thereby reducing overall autophagy levels without affecting lysosomal function. YAP-IN-1 holds promise for research in cancer (e.g., liver cancer, breast cancer, etc.) [1].
Product Specifications
UNSPSC
12352005
Target
YAP
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer
Smiles
C=C(C)[C@@](CC[C@@](C=C)(C)[C@@H]1SC#N)([H])[C@]1([H])C2=CNC3=CC=CC=C32
Molecular Formula
C21H24N2S
Molecular Weight
336.49
References & Citations
[1]Wu Y, et al. Hapalindole Q suppresses autophagosome-lysosome fusion by promoting YAP1 degradation via chaperon-mediated autophagy. Proc Natl Acad Sci U S A. 2024 Dec 10;121 (50) :e2400809121.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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