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EGFR-IN-153

EGFR-IN-153 (Compound 5l) is an EGFR inhibitor. EGFR-IN-153 can inhibit the proliferation (IC50: 0.73 μM) and induce apoptosis of MDA-MB-231 cell. EGFR-IN-153 can be used for the research of breast cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; EGFR

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

N#CC1CCCN1C(CN2C(/C(C3=C2C=CC(Cl)=C3)=N\NC4=NC=C(C5=CC=C(OC)C=C5)S4)=O)=O

Molecular Formula

C25H21ClN6O3S

Molecular Weight

520.99

References & Citations

[1]Alegaon SG, et al. Design, synthesis and molecular dynamics simulations of thiazole-based hydrazones targeting MDA-MB-231 breast cancer cells. Bioorg Chem. 2025 Apr;157:108306.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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