MTOR inhibitor-26
MTOR inhibitor-26 (Compound HPT-11) is an inhibitor of mTOR with an IC50 of 0.7 nM. It effectively inhibits the proliferation of AML cell lines Molm-13 and MV-4-11. mTOR inhibitor-26 exhibits antitumor activity and favorable metabolic stability, making it a promising candidate for cancer research[1].
Product Specifications
UNSPSC
12352005
Target
MTOR
Related Pathways
PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C(NC1=CC=C(C(NC2=C(N)C=CC=C2)=O)C=C1)NC(C=C3)=CC=C3C4=NC(N5C6COCC5CC6)=NC(N7[C@H]8COC[C@@H]7CC8)=N4
Molecular Formula
C35H37N9O4
Molecular Weight
647.73
References & Citations
[1]Li Y, et al. Discovery of highly potent mTOR inhibitors aimed at suppressing the progression of acute myeloid leukemia. Bioorg Chem. 2025 Apr;157:108287.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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