FCOB02

FCOB02 is a monoamine oxidase B (MAO-B) ligand. FCOB02 can be labeled as [18F]FCOB02, a 4-methylcoumarin-like targeting probe. [18F]FCOB02 has a high affinity for MAO-B with an IC50 of 10.68 nM. [18F]FCOB02 can be used in specific MAO-B imaging as well as quantitative analysis in vivo[1].

Product Specifications

CAS Number

[3064236-41-2]

UNSPSC

12352005

Target

Monoamine Oxidase

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

O=C1C=C(C)C(C=CC(OCC2=CN=C(F)C=C2)=C3)=C3O1

Molecular Formula

C16H12FNO3

Molecular Weight

285.27

References & Citations

[1]Zhang Z, et, al. Synthesis and evaluation of a targeted PET radioligand [18F]FCOB02 for monoamine oxidase B. Bioorganic & Medicinal Chemistry Letters. Volume 121, 1 June 2025, 130157.