5-HT4R agonist-2
5-HT4R agonist-2 (Compound 4) is a selective 5-HT4R agonist with an EC50 value of 0.41 nM. 5-HT4R agonist-2 can significantly enhance whole gut and colonic transit, increase fecal output and water content, while maintaining minimal systemic absorption, and it shows promise for the research of chronic idiopathic constipation[1].
Product Specifications
UNSPSC
12352005
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Others
Smiles
O=C(CCCCCN1CCC(CNC(C2=C(OCC3)C3=C(N)C(Cl)=C2)=O)CC1)NCCOCCOCCNC(NCCCCNC(NCCOCCOCCNC(CCCCCN4CCC(CNC(C5=C(OCC6)C6=C(N)C(Cl)=C5)=O)CC4)=O)=O)=O
Molecular Formula
C60H96Cl2N12O12
Molecular Weight
1248.38
References & Citations
[1]Zhang W, et al. Novel gut-restricted bivalent agonists targeting mucosal 5-HT4R: Design, synthesis, and biological evaluation. Eur J Med Chem. 2025 Feb 21;289:117425.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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