α-Glucosidase-IN-86

α-Glucosidase-IN-86 (Compound A4) is an orally active α-glucosidase inhibitor with an IC50 of 2.72 μM. α-Glucosidase-IN-86 has high safety in mice. α-Glucosidase-IN-86 can reduce fasting blood glucose levels, improve glucose tolerance, regulate blood lipids, and has antioxidant effects in diabetic mice. α-Glucosidase-IN-86 can be used for the research of diabetes[1].

Product Specifications

UNSPSC

12352005

Target

Glycosidase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease; Inflammation/Immunology

Smiles

CC1([C@H](CC[C@@]2([C@]3(CC=C4[C@@]5(CC(C)(CC[C@@]5([C@H](O)C[C@]4([C@@]3(CC[C@@]12[H])C)C)C(NCC6=CN(N=N6)C7=CC=C(C(Cl)=C7)Cl)=O)C)[H])[H])C)O)C

Molecular Formula

C39H54Cl2N4O3

Molecular Weight

697.78

References & Citations

[1]Deng H, et al. Design and synthesis of azole derivatives of echinocystic acid as α-glucosidase inhibitors with hypoglycemic activity. Eur J Med Chem. 2025 Feb 22;289:117437.