FDU73
FDU73 is a highly effective and selective BTK PROTAC degrader with a DC50 of 2.9 nM (in JeKo-1 cells) . FDU73 can inhibit the proliferation of tumor cells and exhibits anti-tumor activity[1]. (Pink: BTK ligand-14 (HY-173126) ; Black: Linker (HY-168297) ; Blue: E3 ligase ligand 59 (HY-173378) ; E3 ligase ligand+Linker (HY-173127) )
Product Specifications
UNSPSC
12352005
Target
Btk; PROTACs
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(N[C@@H]1C[C@@H](NC2=C3C(NC=C3C(C4=CC=C(OC5=CC=CC=C5)C=C4)=O)=NC=N2)CC1)CC6CCN(CCC7CCN(C8=NC=C(C(CC9)C(NC9=O)=O)C=C8)CC7)CC6
Molecular Formula
C48H55N9O5
Molecular Weight
838.01
References & Citations
[1]Lin Y, et al. Design, synthesis, and biological evaluation of novel BTK-targeting proteolysis targeting chimeras (PROTACs) with enhanced pharmacokinetic properties. Eur J Med Chem. 2025 Feb 22;289:117420.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-173125/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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