CDK2/FLT4/PDGFRA-IN-1
CDK2/FLT4/PDGFRA-IN-1 (Compound 4a) is a potent inhibitor of CDK2/cyclin A, FLT4 (VEGFR3) and PDGFRA, with IC50s of 1.672, 0.554, and 0.629 μM, respectively. CDK2/FLT4/PDGFRA-IN-1 exhibits potent antiproliferative effects against cancer cells (lung EBC-1, pancreatic ductal adenocarcinoma AsPC-1, colorectal HT-29 cells) . CDK2/FLT4/PDGFRA-IN-1 can also induce apoptosis in cancer cells[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; CDK; PDGFR; VEGFR
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1C(NC2=CC=C(OCC3=CN(CC4=CC=CC=C4)N=N3)C=C2)=CC(C5=C1C=CC=C5)=O
Molecular Formula
C26H20N4O3
Molecular Weight
436.46
References & Citations
[1]Mardaneh P, et, al. Design, synthesis and pharmacological evaluation of 1,4-naphthoquinone- 1,2,3-triazole hybrids as new anticancer agents with multi-kinase inhibitory activity. Sci Rep. 2025 Feb 24;15 (1) :6639.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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