LSD1-IN-40
LSD1-IN-40 (Compound 9e) is a potent LSD1 inhibitor, with an IC50 of 9.85 nM. LSD1-IN-40 exhibits exceptional selectivity for LSD1 over both MAOs and hERG. LSD1-IN-40 exhibits significant inhibitory activity against leukemia cells (MV-4-11, HL-60, and THP-1 cells) . LSD1-IN-40 can induce apoptosis in MV-4-11 cells. LSD1-IN-40 has the potential for the research of acute myeloid leukemia[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Histone Demethylase
Related Pathways
Apoptosis; Epigenetics
Field of Research
Cancer
Smiles
O=S(C1=CC=CC=C1)(N2C(C=CC(N3C=C(CN[C@@H]4C[C@H]4C5=CC=C(F)C(F)=C5)N=N3)=C6)=C6C=N2)=O
Molecular Formula
C25H20F2N6O2S
Molecular Weight
506.53
References & Citations
[1]Huang MJ, et, al. Discovery of novel tranylcypromine-indazole-based derivatives as LSD1 inhibitors for acute myeloid leukemia treatment. Eur J Med Chem. 2025 May 5:289:117438.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC740266-100 1x 100 µL
Human IgG Immunoglobulin (IG266), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC400178-100 1x 100 µL
CD50 (ICAM-3) (186-2G9), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC940689-100 1x 100 µL
Cytokeratin 8 (K8.8), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC941389-100 1x 100 µL
Ferritin, Light Chain (FTL) (Microglia Marker) (FTL/1389), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC400683-500 1x 500 µL
Cytokeratin 7 (OV-TL12/30), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details