LSD1-IN-40
LSD1-IN-40 (Compound 9e) is a potent LSD1 inhibitor, with an IC50 of 9.85 nM. LSD1-IN-40 exhibits exceptional selectivity for LSD1 over both MAOs and hERG. LSD1-IN-40 exhibits significant inhibitory activity against leukemia cells (MV-4-11, HL-60, and THP-1 cells) . LSD1-IN-40 can induce apoptosis in MV-4-11 cells. LSD1-IN-40 has the potential for the research of acute myeloid leukemia[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Histone Demethylase
Related Pathways
Apoptosis; Epigenetics
Field of Research
Cancer
Smiles
O=S(C1=CC=CC=C1)(N2C(C=CC(N3C=C(CN[C@@H]4C[C@H]4C5=CC=C(F)C(F)=C5)N=N3)=C6)=C6C=N2)=O
Molecular Formula
C25H20F2N6O2S
Molecular Weight
506.53
References & Citations
[1]Huang MJ, et, al. Discovery of novel tranylcypromine-indazole-based derivatives as LSD1 inhibitors for acute myeloid leukemia treatment. Eur J Med Chem. 2025 May 5:289:117438.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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