Akt1-IN-8
Akt1-IN-8 (Compound JL18) is a potent and oral bioavailable (41%) inhibitor of AKT1 kinase, with an IC50 of 8.8 nM. Akt1-IN-8 exhibits significant antiproliferative effects against PC-3 prostate cancer cells, with an IC50 of 3.0 μM. Akt1-IN-8 can reduce phosphorylated GSK3β levels[1].
Product Specifications
CAS Number
[2247688-87-3]
UNSPSC
12352005
Target
Akt
Related Pathways
PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C(C(CNC(C)C)C1=CC=C(C=C1)Br)N2CCN(CC2)C3=C4C(Br)=NNC4=NC=N3
Molecular Formula
C21H25Br2N7O
Molecular Weight
551.28
References & Citations
[1]Sun J, et, al. The discovery of novel N-heterocyclic-based AKT inhibitors with potential efficacy against prostate cancer. Eur J Med Chem. 2025 May 5:289:117435.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt1
Curated Selection
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