15-LOX-IN-2
15-LOX-IN-2 (Compound 2a) is an orally active COX-2/15-LOX inhibitor and a partial agonist of PPARγ. 15-LOX-IN-2 has anti-inflammatory activity and inhibits the levels of 20-HETE, IL-1β and TNF-α in RAW 264.7 cells treated with LPS (HY-D1056) . In addition, 15-LOX-IN-2 has significant glucose uptake capacity in the absence of insulin. 15-LOX-IN-2 can be used for the research of metabolic diseases[1].
Product Specifications
UNSPSC
12352005
Target
COX; Interleukin Related; Lipoxygenase; PPAR
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease; Inflammation/Immunology
Smiles
O=C1N=C(N2CCCC2)S/C1=C\C3=CC=C(OCC#C)C=C3
Molecular Formula
C17H16N2O2S
Molecular Weight
312.39
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-173115/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
15-LOX; COX-1; COX-2; IL-1; PPARγ
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