(S, R, S) -AHPC-Boc derivative 1
(S, R, S) -AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1, leading to ubiquitination and subsequent proteasomal degradation of MALT1. (S, R, S) -AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway by disrupting the CBM complex, demonstrating potential for inducing apoptosis in ABC-DLBCL cells. (S, R, S) -AHPC-Boc derivative 1 is promising for research of MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL) [1].
Product Specifications
CAS Number
2086298-33-9
Product Name Alternative
VH032-Boc derivative 1
UNSPSC
12352005
Target
MALT1
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Purity
98.56
Smiles
CC(C)(C)OC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)CO)=O)=O)=O
Molecular Formula
C28H40N4O6S
Molecular Weight
560.71
References & Citations
[1]QIN H, et al. PROTEIN DEGRADATION COMPOUND TARGETING MALT1. WO2023143249A1. 2023-08-03.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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