Me- (S, R, S) -AHPC-CO-CH2-PEG4-O-CH2-COOH
Me- (S, R, S) -AHPC-CO-CH2-PEG4-O-CH2-COOH is the conjugate composed of an E3 ligase ligand and a linker. Me- (S, R, S) -AHPC-CO-CH2-PEG4-O-CH2-COOH can be used for synthesis of PROTAC degrader MS4322.
Product Specifications
CAS Number
2250056-13-2
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
O[C@H]1CN(C([C@@H](NC(COCCOCCOCCOCCOCC(O)=O)=O)C(C)(C)C)=O)[C@H](C(N[C@@H](C)C(C=C2)=CC=C2C3=C(C)N=CS3)=O)C1
Molecular Formula
C35H52N4O11S
Molecular Weight
736.87
References & Citations
[1]Shen Y, et al., Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) Degraders. J Med Chem. 2020 Sep 10;63 (17) :9977-9989.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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