4"- (2- (p-Chlorophenyl) acetoxyl) spiramycin
4"- (2- (p-Chlorophenyl) acetoxyl) spiramycin (Compound 2d) is a broad-spectrum anti-coronaviral agent via targeting frameshifting element (FSE) . 4"- (2- (p-Chlorophenyl) acetoxyl) spiramycin inhibits HCoV-OC43 and HCoV-229E with EC50 values of 0.85 μM and 1.45 μM. 4"- (2- (p-Chlorophenyl) acetoxyl) spiramycin shows a dual-target mechanism that acts on both viral FSE RNA and host DIS3L2[1].
Product Specifications
UNSPSC
12352005
Target
SARS-CoV
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
O=C1O[C@H](C)C/C=C/C=C/[C@H](O[C@@H]2O[C@H](C)[C@@H](N(C)C)CC2)[C@H](C)C[C@H](CC=O)[C@H](OC3[C@H](O)[C@@H](N(C)C)[C@H](O[C@@H]4O[C@@H](C)[C@H](OC(CC5=CC=C(Cl)C=C5)=O)[C@@](O)(C)C4)[C@H](C)O3)[C@@H](OC)[C@H](O)C1
Molecular Formula
C51H79ClN2O15
Molecular Weight
995.63
References & Citations
[1]Zhong X, et al. Synthesis and evolution of 16-membered macrolide carrimycin derivatives as a novel class of anti-HCoV-OC43 agents targeting viral FSE RNA. Eur J Med Chem. 2025 Apr 5;287:117373.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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