TLR7 agonist 30

TLR7 agonist 30 (compound 2) is an agent-linker conjugate for ADC. TLR7 agonist 30 contains a TLR7 agonist (compound 1) and a cleavable linker, and has potent anti-tumor activity[1].

Product Specifications

UNSPSC

12352005

Target

Drug-Linker Conjugates for ADC; Toll-like Receptor (TLR)

Related Pathways

Antibody-drug Conjugate/ADC Related; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

OC1=NC2=C(N)N=C(OCCCC)N=C2N1CC3=CN=C(CN(C4CCC4)C(OCC5=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCN)=O)=O)=O)C=C5C(NCCNC(CCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)=O)C=C3

Molecular Formula

C71H115N15O22

Molecular Weight

1530.76

References & Citations

[1]Sega E, et al. Targeted Delivery of TLR7 Agonists to the Tumor Microenvironment Enhances Tumor Immunity via Activation of Tumor-Resident Myeloid Cells. Bioconjug Chem. 2025 Feb 13.