PD-L1/LpxC-IN-1
PD-L1/LpxC-IN-1 (Conpound 12b) is the inhibitor for PD-L1 and LpxC with IC50 of 5.2 μM and 0.081 μM. PD-L1/LpxC-IN-1 inhibits the biosynthesis of bacterial lipopolysaccharide, causes the lysis and death of bacterial cells. PD-L1/LpxC-IN-1 inhibits Gram-negative bacteria, MIC for K. pneumoniae ATCC 13883, E. coli ATCC 8739, S. typhimurium ATCC 14028 and P. aeruginosa ATCC 9027 is 0.25-0.5 μg/mL. PD-L1/LpxC-IN-1 downregulates the expression of inflammatory factors IL-2 and IFN-γ, upregulates the expression of CD4+ and CD8+ cells, thereby activating the immune system and inhibiting excessive inflammatory responses. PD-L1/LpxC-IN-1 exhibits antibacterial activity in K. pneumoniae ATCC 13883 infected mouse models[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial; PD-1/PD-L1
Related Pathways
Anti-infection; Immunology/Inflammation
Field of Research
Infection; Inflammation/Immunology
Smiles
CC1=C(C2=CC=CC=C2)C=CC=C1COC3=CC=CC(CNC(C(O)C)C(NO)=O)=C3
Molecular Formula
C25H28N2O4
Molecular Weight
420.50
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-173077/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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