HDAC11-IN-1
HDAC11-IN-1 (Compound 14-NC6OH) is a selective macrocyclic inhibitor of HDAC11 with a Ki of 40 nM. HDAC11-IN-1 exhibits good cell permeability and can inhibit the expression of YAP1 and SOX2[1].
Product Specifications
UNSPSC
12352005
Target
HDAC; YAP
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Stem Cell/Wnt
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Smiles
FC(F)(C1=CC=CC=C1C[C@@H](C(N[C@@H]([C@H](CC)C)C(N[C@@H](CCCCCC(N(CCCCCC)O)=O)C(NCCCSC2)=O)=O)=O)NC(CCSCC3=CC=CC2=N3)=O)F
Molecular Formula
C43H63F3N6O6S2
Molecular Weight
881.12
References & Citations
[1]Danková D, et al. Discovery of De Novo Macrocycle Inhibitors of Histone Deacetylase 11. JACS Au. 2025 Feb 16;5 (3) :1299-1307.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
HDAC11
Curated Selection
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