Microtubulin-IN-1

Microtubulin-IN-1 (Compound 8g) is the inhibitor for microtubulin that targets colchicine-binding site, disrupts the microtubulin integrity, and induces the upregulation of p53. Microtubulin-IN-1 exhibits antiproliferative activity in a variety of cancer cell lines (IC50 for NCI-H460, BxPC-3 and HT-29 is 2.4, 1.6 and 2.07 nM, respectively), arrests the cell cycle at G2/M phase, and induces apoptosis in NCI-H460[1].

Product Specifications

CAS Number

[3025180-14-4]

UNSPSC

12352005

Target

Apoptosis; MDM-2/p53; Microtubule/Tubulin

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Smiles

FC1=CC=C(C(C2=CC=CC(/C=C3NC(/C(NC\3=O)=C/C4=NC=CN4C(C)C)=O)=C2)=O)C=C1

Molecular Formula

C25H21FN4O3

Molecular Weight

444.46

References & Citations

[1]Chen N, et al., Design, synthesis and anticancer evaluation of novel 1,3-imidazole-type phenylhistin derivatives: Dual mechanism via P53 induction and microtubulin inhibition. Bioorg Chem. 2025 Apr;157:108271.