NU227326

NU227326 is the PROTAC degrader for Indoleamine 2,3-dioxygenase 1 (IDO1) with DC50 of 4.5 nM. NU227326 degrades IDO1 in cell U87 and GBM43 with DC50 of 7.1 nM and 11.8 nM. NU227326 exhibits good pharmacokinetic properties with a plasma half-life of 5.7 hours and a brain tissue half-life of 11.8 hours[1]. (Pink: ligand for target protein IDO1 ligand-1 (HY-173067) ; Black: linker (HY-173068) ; Blue: ligand for E3 ligase Cereblon (HY-W087383) )

Product Specifications

CAS Number

[3048196-52-4]

UNSPSC

12352005

Target

Indoleamine 2,3-Dioxygenase (IDO) ; PROTACs

Related Pathways

Metabolic Enzyme/Protease; PROTAC

Field of Research

Cancer

Smiles

O=C(NC1=CC=CC(OC2CCN(C(CN3CCC(N4CCN(C5=CC6=C(C(N(C(CC7)C(NC7=O)=O)C6=O)=O)C=C5)CC4)CC3)=O)CC2)=C1)[C@H](C)[C@@]8([H])CC[C@](C9=C%10C(C=CC(F)=C%10)=NC=C9)([H])CC8

Molecular Formula

C53H61FN8O7

Molecular Weight

941.10

References & Citations

[1]Monsen PJ, et al., Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC) . J Med Chem. 2025 Feb 27;68 (4) :4961-4987.