TLR8 antagonist-1
TLR8 antagonist-1 (Compound 10) is a selective TLR8 antagonist. TLR8 antagonist-1 can inhibit TLR8-mediated inflammation and signaling pathways, reduce the recruitment of MyD88, and inhibit the NF-κB and IRF pathways. TLR8 antagonist-1 has anti-inflammatory activity[1].
Product Specifications
CAS Number
1111460-83-3
UNSPSC
12352005
Target
MyD88; NF-κB; Toll-like Receptor (TLR)
Related Pathways
Immunology/Inflammation; NF-κB
Field of Research
Inflammation/Immunology
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=NOC(C)=C1COC2=C(OC)C=C(C(NC3CCN(CC)CC3)=O)C=C2
Molecular Formula
C21H29N3O4
Molecular Weight
387.47
References & Citations
[1]Matziol T, et al. Discovery of Novel Isoxazole-Based Small-Molecule Toll-Like Receptor 8 Antagonists. J Med Chem. 2025 Feb 27;68 (4) :4888-4907.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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