BRD4 Inhibitor-40

BRD4 Inhibitor-40 (Compound 23) is the inhibitor for BRD that inhibits BRD4-BD1, BRD4-BD2, BRD2-BD1 and BRD2-BD2 with IC50s of 16.1, 142.18, 29.35 and 302.35 nM, respectively. BRD4 Inhibitor-40 modulates the expression of c-Myc and p21, arrests cell cycle at G1 phase, inhibits Pkd1-null (PN) renal cystic epithelial cells, and blocks the renal cysts formation in Madin-Darby canine kidney and embryonic kidney vesicle models. BRD4 Inhibitor-40 exhibits renal cysts inhibitory activity in mouse models[1].

Product Specifications

CAS Number

[2994635-04-8]

UNSPSC

12352005

Target

C-Myc; Epigenetic Reader Domain

Related Pathways

Apoptosis; Epigenetics

Field of Research

Others

Smiles

CC(N1C2=CC(NC3=NC(CC)=CC(NC4=NN(C)C5=CC=CC=C45)=N3)=CC=C2N(C([C@H]1C)=O)C)C

Molecular Formula

C27H32N8O

Molecular Weight

484.60

References & Citations

[1]Yang Y, et al., Design of Selective BRD4 Inhibitors for the Treatment of Autosomal Dominant Polycystic Kidney Disease. J Med Chem. 2025 Mar 13;68 (5) :5257-5274.