BMX-IN-3
BMX-IN-3 (B6a) is an irreversible and selective BMX inhibitor, with an IC50 of 12 nM. BMX-IN-3 (B6a) promots cell cycle arrest and apoptosis, triggers protective autophagy, and suppresses the BMX/AKT/mTOR pathway. BMX-IN-3 (B6a) can be used in the research for Gastric Carcinoma [1].
Product Specifications
CAS Number
2657662-64-9
UNSPSC
12352005
Target
Apoptosis; Autophagy; BMX Kinase
Related Pathways
Apoptosis; Autophagy; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
NC1=NC(NC2=CC=CC(OC3=CC=CC=C3)=C2)=NC(N[C@@H]4CCCN(C4)S(C=C)(=O)=O)=N1
Molecular Formula
C22H25N7O3S
Molecular Weight
467.54
References & Citations
[1]Nan Wang, Design, Synthesis, and Mechanism Study of Novel BMX Inhibitors Based on the Core of 1,3,5-Triazin-2-Amine for the Treatment of Gastric Carcinoma. J Med Chem. 2025 Feb 27;68 (4) :4196-4216.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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