Ferroleuton
Ferroleuton is a competitive, selective inhibitor for 5-lipoxygenase with an IC50 of 0.21 μM. Ferroleuton exhibits antioxidant activity in DPPH (scavenges 86% DPPH-H at 50 μM), ABTS (EC50=19.42 μM) and FRAP (EC50=3.32 μM) assays[1].
Product Specifications
UNSPSC
12352100
Target
Lipoxygenase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
[][Fe][].CC(c1cccc1)N(O)C(N)=O.c2cccc2
Molecular Formula
C13H16FeN2O2
Molecular Weight
288.12
References & Citations
[1]Navarrete E, et al., Development of Ferrocenyl and Ruthenocenyl Zileuton Analogs with Enhanced Bioactivity toward Human 5-Lipoxygenase: Innovation in Drugs for Inflammatory Diseases. Inorg Chem. 2025 Feb 24;64 (7) :3495-3505.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-LOX
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