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HDAC-IN-87

HDAC-IN-87 (Compound XII6) is a nonselective HDAC inhibitor, with pIC50 of 6.9 (HDAC4) and 5.8 (HDAC6) respectively. HDAC-IN-87 has fungicidal activity against P. sorghi and P. pachyrhizi. HDAC-IN-87 shows an acute oral LD50 of greater than 500 mg/kg in male and female rats[1].

Product Specifications

CAS Number

3039482-69-1

UNSPSC

12352005

Target

Fungal; HDAC

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Epigenetics

Field of Research

Infection

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC(C1=NC(C2=CC=C(COC3=NC=NC(C(F)F)=C3)S2)=NO1)(F)F

Molecular Formula

C13H7F5N4O2S

Molecular Weight

378.28

References & Citations

[1]Liu XH, et al. Novel 5- (Trifluoromethyl) -1,2,4-oxadiazole-Based Pyrimidin-4-ether Histone Deacetylase Inhibitors for Controlling Rust Disease: Design, Synthesis, Activity, and Structure-Activity Relationship. J Agric Food Chem. 2025 Feb 26;73 (8) :4563-4573.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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