HDAC-IN-87
HDAC-IN-87 (Compound XII6) is a nonselective HDAC inhibitor, with pIC50 of 6.9 (HDAC4) and 5.8 (HDAC6) respectively. HDAC-IN-87 has fungicidal activity against P. sorghi and P. pachyrhizi. HDAC-IN-87 shows an acute oral LD50 of greater than 500 mg/kg in male and female rats[1].
Product Specifications
CAS Number
3039482-69-1
UNSPSC
12352005
Target
Fungal; HDAC
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Infection
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(C1=NC(C2=CC=C(COC3=NC=NC(C(F)F)=C3)S2)=NO1)(F)F
Molecular Formula
C13H7F5N4O2S
Molecular Weight
378.28
References & Citations
[1]Liu XH, et al. Novel 5- (Trifluoromethyl) -1,2,4-oxadiazole-Based Pyrimidin-4-ether Histone Deacetylase Inhibitors for Controlling Rust Disease: Design, Synthesis, Activity, and Structure-Activity Relationship. J Agric Food Chem. 2025 Feb 26;73 (8) :4563-4573.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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