NLRP3-IN-71

NLRP3-IN-71 (Compound 19) is a BBB-permeable, orally active and selective NLRP3 inhibitor that can inhibit IL-1β secretion. NLRP3-IN-71 can be used for the research of neurodegenerative diseases[1].

Product Specifications

CAS Number

[3026419-44-0]

UNSPSC

12352005

Target

Interleukin Related; NOD-like Receptor (NLR)

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

OC(C=C(C=C1)C(F)(F)F)=C1C2=NN=C(C3=NC=CN32)N[C@H]4CN(CCC4)C

Molecular Formula

C18H19F3N6O

Molecular Weight

392.38

References & Citations

[1]Mammoliti O, et al. Discovery of Potent and Brain-Penetrant Bicyclic NLRP3 Inhibitors with Peripheral and Central In Vivo Activity. J Med Chem. 2025 Feb 27;68 (4) :4848-4887.