5-HT6R antagonist 6
5-HT6R antagonist 6 exhibits high affinity and selectivity for 5-HT6R , with a Ki value of 42 nM. 5-HT6R antagonist 6 shows weak antiproliferative activity against tumor cells and low toxicity to normal cells. 5-HT6R antagonist 6 can be used in the study of cancer[1].
Product Specifications
UNSPSC
12352005
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=S(C1=C2C=CC=CC2=CC=C1)(NCCCCCCNC3=NC=C4C=CC=CC4=N3)=O
Molecular Formula
C24H26N4O2S
Molecular Weight
434.55
References & Citations
[1]Zaręba P, et al. Long-Chain Cyclic Arylguanidines as Multifunctional Serotonin Receptor Ligands with Antiproliferative Activity. ACS Omega. 2025 Feb 11;10 (7) :6446-6469.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT6 Receptor; MUC2
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