5-HT6R antagonist 6

5-HT6R antagonist 6 exhibits high affinity and selectivity for 5-HT6R , with a Ki value of 42 nM. 5-HT6R antagonist 6 shows weak antiproliferative activity against tumor cells and low toxicity to normal cells. 5-HT6R antagonist 6 can be used in the study of cancer[1].

Product Specifications

UNSPSC

12352005

Target

5-HT Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=S(C1=C2C=CC=CC2=CC=C1)(NCCCCCCNC3=NC=C4C=CC=CC4=N3)=O

Molecular Formula

C24H26N4O2S

Molecular Weight

434.55

References & Citations

[1]Zaręba P, et al. Long-Chain Cyclic Arylguanidines as Multifunctional Serotonin Receptor Ligands with Antiproliferative Activity. ACS Omega. 2025 Feb 11;10 (7) :6446-6469.